Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1475, Issue 3, Pages 346-352Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0304-4165(00)00088-X
Keywords
bola-amphiphile; peptide fiber; L-valyl-L-valine; self-assembly; beta-sheet; FT-IR spectroscopy
Categories
Ask authors/readers for more resources
A series of dipeptide-based bola-amphiphiles, bis(N-alpha-amide-L-valyl-L-valine) 1, n-alkane dicarboxylate (n = 4-12), have been synthesized. The bola-amphiphiles with n = 4 and 6 self-assembled to form crystalline solids in water, whereas those with n = 7-12 produced peptide fibers. FT-IR spectroscopy and X-ray diffraction patterns revealed that the peptide fibers have parallel-type beta-sheet networks between the valylvaline units. FT-IR deconvolution study of carboxyl regions indicated that these crystalline solids and peptide fibers are stabilized by interlayer bifurcated and intralayer lateral hydrogen-bond networks between the end carboxylic acid groups, respectively. (C) 2000 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available