Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1502, Issue 1, Pages 122-132Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4439(00)00038-7
Keywords
Alzheimer's disease; paired helical filament; tau protein; self-assembly; nucleation
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Over the past few years the systematic investigation of paired helical filament assembly from tau protein in vitro has become feasible. We review our current understanding of the structure and conformations of tan protein and how this affects tau's assembly into the pathological paired helical filaments in Alzheimer's disease. (C) 2000 Elsevier Science B.V. All rights reserved.
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