Palladium-catalyzed intramolecular coupling of vinyl halides and ketone enolates, synthesis of bridged azabicyclic compounds

[GRAPHICS] The palladium-mediated intramolecular coupling of amino-tethered vinyl halides and ketone enolates is a useful methodology for the synthesis of nitrogen heterocycles and constitutes a new synthetic entry to the 2-azabicyclo[3.3.1]nonane framework, A study about the reaction conditions and the scope of the process is reported.