Journal
REGULATORY PEPTIDES
Volume 91, Issue 1-3, Pages 45-62Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0167-0115(00)00138-5
Keywords
renin-angiotensin system; multiple mediator system; angiotensin-(1-7)
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The renin-angiotensin system is a major physiological regulator of arterial pressure and hydro-electrolyte balance. Evidence has now been accumulated that in addition to angiotensin (Ang) II other Ang peptides [Ang III, Ang IV and Ang-(1-7)], formed in the limited proteolysis processing of angiotensinogen, are importantly involved in mediating several actions of the RAS. In this article we will review our knowledge of the biological actions of Ang-(1-7) with focus on the puzzling aspects of the mediation of its effects and the interaction Ang-(1-7)-kinins. In addition, we will attempt to summarize the evidence that Ang-(1-7) takes an important part of the mechanisms aimed to counteract the vasoconstrictor and proliferative effects of Ang II. (C) 2000 Elsevier Science B.V. All rights reserved.
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