Journal
BIOLOGICAL PSYCHOLOGY
Volume 79, Issue 2, Pages 148-157Publisher
ELSEVIER
DOI: 10.1016/j.biopsycho.2008.04.003
Keywords
Down syndrome; Event-related potential; Auditory; T-complex; Speech sounds; Tones; Lateralisation
Funding
- The Wellcome Trust
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It has long been argued that abnormal cerebral lateralisation might underlie the language problems that characterise Down syndrome, but to date only behavioural evidence has been provided. We used the auditory event-related potentials Ta and Tb of the T-complex to investigate lateralised processing of speech (vowels) and non-speech (simple and complex tones) sounds in children with Down syndrome and age-matched typically developing children. We also explored associations with speech and language abilities. Although changes in the Ta and Tb in response to increases in stimulus complexity and 'speechness' were similar across group, the Tb peak was delayed in children with Down syndrome across conditions. In addition, marked differences in the patterns of lateralisation of Ta latency and Tb amplitude were observed in children with Down syndrome, in response to both speech and non-speech sounds. No associations were found between Ta and Tb characteristics and speech and language abilities in children with DS. (C) 2008 Elsevier B.V. All rights reserved.
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