The initial pathogenesis of cadmium induced renal toxicity

The novel application of magic angle spinning H-1 NMR spectroscopy, coupled with pattern recognition techniques, has identified biochemical changes in lipid and glutamate metabolism that precede classical nephrotoxicity. These changes occurred in the bank vole (Clethrionomys glareolus) after chronic dosing, at a low level of exposure and at a renal CD2+ concentration (8.4 mu g/g dry wt) that was nearly two orders of magnitude below the WHO critical organ concentration (200 mu g/g wet wt). These early stage effects of Cd2+ on the biochemistry of renal tissue may reflect adaptation mechanisms to the toxic insult or the preliminary stages of the toxicological cascade, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.