Journal
JOURNAL OF CONTROLLED RELEASE
Volume 68, Issue 1, Pages 63-72Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-3659(00)00233-9
Keywords
periodontal wafers; silver nitrate; antimicrobial agent; staining
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Periodontal wafers intended to treat the underlying infections in patients with periodontitis have been developed. The wafers consist of poly(lactic-co-glycolic acid) as a primary bioerodible polymeric component, poly(ethylene glycol) as a plasticizer and encapsulation aid, and silver nitrate as the antimicrobial agent. The wafers are capable of sustained in vitro release of bioactive silver for at least 4 weeks. The wafers exhibit silver release that follows erosion kinetics, confirming a bulk erosion/release mechanism. In clinical evaluation, sustained release of silver at bactericidal levels for at least 21 days is observed. Staining of hard and soft tissues due to the released silver is minimal and reversible. (C) 2000 Elsevier Science B.V. All rights reserved.
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