Journal
TRENDS IN CELL BIOLOGY
Volume 10, Issue 8, Pages 329-335Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(00)01798-0
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The yeast spindle pole body (SPB) is the functional equivalent of the centrosome and forms the two poles of the mitotic spindle. Before mitosis, both SPBs and centrosomes are present as single copies and must be duplicated to form the bipolar spindle. SPB components have been identified using a combination of biochemistry and genetics, and their role during SPB duplication has been analysed using temperature-sensitive mutants. In this article, we describe structural aspects of SPB duplication and their possible relationship to centrosome duplication.
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