Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 11, Issue 4, Pages 267-275Publisher
ACADEMIC PRESS LTD
DOI: 10.1006/scdb.2000.0175
Keywords
glucose metabolism; insulin secretion; ATP/ADP ratio; long-chain Acyl-CoA; nutrient regulation
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Funding
- NIDDK NIH HHS [DK35914] Funding Source: Medline
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Glucose-induced insulin secretion is pulsatile. Glucose metabolism generates oscillations in the ATP/ADP ratio which lead to opening and closing of ATP-sensitive K+-channels producing subsequent oscillations in membrane potential, cytoplasmic calcium and insulin release. Metabolic signals derived from glucose can also stimulate insulin release independent of their effects on ATP-sensitive K+-channels. The ATP/ADP ratio may mediate both ATP-sensitive K+-channel-dependent and -independent pathways of secretion. Glucose metabolism also results in an increase in long-chain acyl-CoA, which is proposed to act as an effector molecule in the beta-cell. Long-chain acyl-CoA has a variety of effects in the beta-cell that may effect insulin secretion including opening ATP-sensitive K+-channels, activating endoplasmic reticulum Ca2+-ATPases and stimulating classical protein ki nase C activity. In addition to stimulating insulin release, nutrients also effect gene expression, protein synthesis and beta-cell proliferation. Gene expression is effected by nutrient induction of a variety of immediate early response genes. Glucose stimulates proinsulin biosynthesis both at the translational and transcriptional level. beta-cell proliferation, as a result of insulin-like growth factor and growth hormone mitogenic pathways, is also glucose dependent. Thus, many beta-cell functions in addition to secretion are controlled by nutrient metabolism.
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