Journal
JOURNAL OF NEUROLOGY
Volume 247, Issue 8, Pages 630-632Publisher
DR DIETRICH STEINKOPFF VERLAG
DOI: 10.1007/s004150070132
Keywords
botulinum toxin therapy; therapy failure; antibodies; electromyography
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In a small number of patients treated with botulinum toxin (BT) antibody (Ab) formation occurs. BT Ab can be detected by the mouse protection assay (MPA) or by the mouse diaphragm assay (MDA). Both methods, however have major drawbacks. We tested a method for detecting BT Ab which measures the BT-induced reduction in the electromyographic amplitude of the mean maximal voluntary activation (M-EMG) of the sternocleidomastoid muscle. The M-EMG reduction was compared in 17 patients with cervical dystonia and secondary BT therapy failure to the M-EMG reduction previously measured in controls. Values more than 2 SD below the mean of controls were considered abnormal. Six patients showed BT Ab on the MPA and MDA; all of these had abnormal M-EMG reductions. Eleven patients showed no BT Ab on MPA and MDA testing; in ten of these the M-EMG reduction was normal, and in one it was pathological, but MDA testing later changed to positive under continued BT therapy. The sternocleidomastoid test is easy to per form and produces quantitative results. Since its sensitivity and specificity an at least as good as those of the MDA and the MPA, it can replace them.
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