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The Neurobiological Underpinnings of Obesity and Binge Eating: A Rationale for Adopting the Food Addiction Model

Journal

BIOLOGICAL PSYCHIATRY
Volume 73, Issue 9, Pages 804-810

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2012.08.026

Keywords

Addiction; binge eating; dopamine; drug abuse; obesity; opioid

Funding

  1. Cambridge Overseas Trust
  2. Lilly
  3. GlaxoSmithKline
  4. Lundbeck
  5. Medical Research Council [G00001354]
  6. Wellcome Trust [G00001354]
  7. Medical Research Council [G0001354B, G1000183B, G0001354] Funding Source: researchfish

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The food addiction model of overeating has been proposed to help explain the widespread advancement of obesity over the last 30 years. Parallels in neural substrates and neurochemistry, as well as corresponding motivational and behavioral traits, are increasingly coming to light; however, there are still key differences between the two disorders that must be acknowledged. We critically examine these common and divergent characteristics using the theoretical framework of prominent drug addiction models, investigating the neurobiological underpinnings of both behaviors in an attempt to justify whether classification of obesity and binge eating as an addictive disorder is merited.

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