Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 10, Issue 4, Pages 387-392Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(00)00101-5
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Several advances have been made in our understanding of the control of the growth and patterning of embryonic limbs. Development of the vertebrate limb is dependent on reciprocal interactions between the ectoderm and mesoderm that regulate the structure and function of the apical ectodermal ridge. One key component of this regulatory program appears to be the precise control of signaling by members of the bone morphogenetic protein family via multiple antagonistic interactions.
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