Journal
NATURE IMMUNOLOGY
Volume 1, Issue 2, Pages 145-150Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/77827
Keywords
-
Categories
Ask authors/readers for more resources
We show here that priming and memory generation of antigen-specific CD8(+) cytotoxic T lymphocytes (CTL) does not require help if the immunogen binds major histocompatibility complex (MHC) class I molecules with high affinity. This conclusion was based on the study of three chemically distinct optimal length CTL epitopes with high affinity for the restriction element K-b. In contrast, when two subdominant epitopes with intermediate MHC binding affinity were studied, either a class II MHC-restricted T helper cell epitope or administration of antibody to CD40 was required to obtain significant CTL priming. Depending on the epitope, one source of help was much more efficient than the other.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available