Journal
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
Volume 56, Issue -, Pages 1067-1069Publisher
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S0907444900006776
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The haemagglutinin HA is a trimer of identical subunits and is the more abundant viral surface glycoprotein of the influenza virus. It is the target of antibodies that neutralize viral infectivity. Antibodies that bind to HA with 3:1 and 1:1 stoichiometries have been identified. Here, an antibody whose Fab binds to HA with an unprecedented 2:1 Fab:HA stoichiometry is characterized. The complex has been crystallized and synchrotron data to 3.5 Angstrom resolution have been collected. Molecular replacement confirms the stoichiometry of the complex.
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