Journal
IMMUNITY
Volume 13, Issue 2, Pages 243-253Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(00)00024-8
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Funding
- NCI NIH HHS [CA81140] Funding Source: Medline
- NICHD NIH HHS [HHD37091] Funding Source: Medline
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Pre-B cell receptor (pre-BCR) expression is critical for B lineage development. The signaling events initiated by the pre-BCR, however, remain poorly defined. We demonstrate that lipid rafts are the major functional compartment for human pre-B cell activation. A fraction of pre-BCR was constitutively raft associated, and receptor engagement enhanced this association. These events promoted Lyn activation and Ig beta phosphorylation and led to the generation of a raft-associated signaling module composed of tyrosine phosphorylated Lyn, Syk, BLNK, PI3K, Btk, VAV, and PLC gamma P. Formation of this module was essential for pre-BCR calcium signaling. Together, these observations directly link the previously identified genetic requirement for the components of this module in B lineage development with their functional role(s) in human pre-BCR signaling.
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