Journal
BIOLOGICAL PSYCHIATRY
Volume 72, Issue 8, Pages 707-709Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2012.03.011
Keywords
Fasting glucose; genome-wide association studies (GWAS); genome-wide complex trait analysis (GCTA); height; major depressive disorder (MDD); missing heritability; smoking
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Funding
- Genetic Association Information Network of the Foundation for the U.S. National Institutes of Health
- Netherlands Organization for Scientific Research (NWO: MagW/ZonMW) [Addiction-31160008, 40-0056-98-9032, SPI 56-464-14192]
- Geestkracht [10-000-1002]
- Netherlands Study of Depression and Anxiety (NESDA) (Geestelijke Gezondheidszorg [GGZ] Buitenamstel-Geestgronden, Rivierduinen
- University Medical Center Groningen
- GGZ Lentis
- GGZ Friesland
- GGZ Drenthe
- Centre for Medical Systems Biology (NWO Genomics)
- Netherlands Bioinformatics Center/BioAssist/RK/2008.024
- Institute for Health and Care Research (EMGO+)
- Neuroscience Campus Amsterdam
- Biobanking and Biomolecular Resources Research Infrastructure Grant [NL-184.021.007]
- European Science Council [230374]
- Rutgers University (National Institute of Mental Health) [U24 MH068457-06]
- National Institute on Drug Abuse [DA018673]
- Royal Netherlands Academy of Arts and Science [ISK/6827/VPPl]
- Veni Grant [451-06-004, 916.76.125]
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Genome-wide association studies of psychiatric disorders have been criticized for their lack of explaining a considerable proportion of the heritability established in twin and family studies. Genome-wide association studies of major depressive disorder in particular have so far been unsuccessful in detecting genome-wide significant single nucleotide polymorphisms (SNPs). Using two recently proposed methods designed to estimate the heritability of a phenotype that is attributable to genome-wide SNPs, we show that SNPs on current platforms contain substantial information concerning the additive genetic variance of major depressive disorder. To assess the consistency of these two methods, we analyzed four other complex phenotypes from different domains. The pattern of results is consistent with estimates of heritability obtained in twin studies carried out in the same population.
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