Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 37, Issue 2-3, Pages 317-329Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0197-0186(00)00033-4
Keywords
astroglia; glutamate; glutamate receptors; glutamate transport; cell volume; glial network
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Astroglia have the capacity to monitor extracellular glutamate (Glu) and maintain it at low levels, metabolize Glu, or release it back into the extracellular space. Glu can induce an increase in astroglial cell volume with a resulting decrease of the extracellular space, and thereby alter the concentration of extracellular substances. Many lines of evidence show that K+ can be buffered within the astroglial gap-junction-coupled network. and recent results show that gay junctions are permeable for Glu. All these events occur dynamically: the astroglial network has the capacity to interfere actively with neurotransmission, thereby contributing to a high signal-to-noise ratio for the Gln transmission. High-quality neuronal messages during normal physiology can then be maintained. With the same mechanisms, astroglia might exert a neuroprotective function in situations of moderately increased extracellular Glu concentrations, i.e,, corresponding to conditions of pathological hyper-excitability, or corresponding to early stages of an acute brain injury. If the astroglial functions are failing, neuronal dysfunction can be reinforced. (C) 2000 Elsevier Science Ltd. All rights reserved.
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