Journal
NATURE CELL BIOLOGY
Volume 2, Issue 8, Pages E153-E157Publisher
MACMILLAN PUBLISHERS LTD
DOI: 10.1038/35019643
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Ubiquitin functions by covalently modifying other proteins. In the past few years, a surprising number of other proteins have been identified that, despite often being only slightly similar to ubiquitin, can also be attached to proteins. Newly discovered parallels between the activation of ubiquitin and the biosynthesis of certain enzyme cofactors now hint at the possible evolutionary origins of the ubiquitin system.
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