Journal
AMERICAN JOURNAL OF PATHOLOGY
Volume 157, Issue 2, Pages 401-410Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0002-9440(10)64553-1
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Funding
- NIA NIH HHS [P50 AG005131, AG10869, AG5131] Funding Source: Medline
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Abnormal accumulation of the presynaptic protein alpha-synuclein has recently been implicated in the pathogenesis of Alzheimer's and Parkinson's diseases. Because neurodegeneration in these conditions might be associated with mitochondrial dysfunction and oxidative stress, the effects of alpha-synuclein were investigated in a hypothalamic neuronal cell. line (GT1-7). alpha-Synuclein overexpression in these cells resulted in formation of alpha-synuclein-immunopositive inclusion-like structures and mitochondrial alterations accompanied by increased levels of free radicals and decreased secretion of gonadotropin-releasing hormone. These alterations were ameliorated by pretreatment with anti-oxidants such as vitamin E. Taken together these results suggest that abnormal accumulation of alpha-synuclein could lead to mitochondrial alterations that may result In oxidative stress and, eventually, cell death.
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