Journal
BIOLOGICAL PSYCHIATRY
Volume 69, Issue 12, Pages E43-E54Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2010.09.041
Keywords
Animal models; devaluation; emotion; frontal lobe function; mood; primate research; reversal; reward; self-esteem; self-reflection; self-valuation; self-worth
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Funding
- National Institute of Mental Health
- Pfizer Pharmaceuticals
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Despite considerable effort, the localization of dysfunction in major depressive disorder (MDD) remains poorly understood. We present a hypothesis about its localization that builds on recent findings from primate neuropsychology. The hypothesis has four key components: a deficit in the valuation of self underlies the core disorder in MDD; the medial frontal cortex represents self; interactions between the amygdala and cortical representations update their valuation; and inefficiency in using positive feedback by orbital prefrontal cortex contributes to MDD.
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