Journal
PIGMENT CELL RESEARCH
Volume 13, Issue 4, Pages 260-272Publisher
WILEY
DOI: 10.1034/j.1600-0749.2000.130408.x
Keywords
cadherin; catenin; plakoglobin; Mitf; mouse; melanocyte; melanoma; melanoblast; development; differentiation
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Cadherins are calcium-dependent cell adhesion receptors with strong morphoregulatory functions, To mediate functional adhesion, cadherins must interact with actin cyto-skeleton. Catenins are cytoplasmic proteins that mediate the interactions between cadherins and the cytoskeleton. In addition to their role in cell-cell adhesion, catenins also participate in signaling pathways that regulate cell growth and differentiation. Cadherins and catenins appear to be involved in melanocyte development and transformation. Here, we investigated the function of cadherin-catenin complexes in the normal development and transformation of melanocytes by studying the patterns of expression of the cell-cell adhesion molecules, E-, N- and P-cadherin, and the expression of their cytoplasmic partners, alpha-, beta- and gamma-catenin during murine development. Similar analyses were performed in vitro using murine melanoblast, melanocyte, and melanoma cell lines in the presence and absence of keratinocytes, the cells with which melanocytes interact in vivo. Overall, the results suggest that the expression of cadherins and catenins is very plastic and depends on their environment as well as the transformation status of the cells. This plasticity is important in fundamental cellular mechanisms associated with normal and pathological ontogenesis, as well as with tumorigenesis.
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