Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 25, Issue 8, Pages 352-356Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(00)01589-9
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Iron-sulfur (Fe-S) cluster-containing proteins perform important tasks in catalysis, electron transfer and regulation of gene expression. In eukaryotes! mitochondria are the primary site of cluster formation of most Fe-S proteins. Assembly of the Fe-S clusters is mediated by the iron-sulphate cluster assembly (ISC) machinery consisting of some ten proteins.
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