Journal
BIOLOGICAL PSYCHIATRY
Volume 65, Issue 11, Pages 927-934Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2009.01.027
Keywords
Alzheimer's disease; A beta 42; [C-11]PiB; CSF; [F-18]FDG; positron emission tomography; Pittsburgh Compound B
Categories
Funding
- The German research foundation [HF 4560/1-2, DR 445/3-1, DR 445/4-1]
- National Institutes of Health [R01 AG018402, R37 AG025516, P01 AG025204]
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Background: A decreased concentration of beta amyloid (1-42) (A beta 42) has consistently been found in the cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) and is considered a diagnostic biomarker. However, it is not clear to which extent CSF A beta 42 levels are reflective of cerebral pathology in AD. The aim of the study was to determine the association between cerebral amyloid plaque load, as measured by means of the positron emission tomography (PET) tracer carbon-11-labeled Pittsburgh Compound B ([C-11]PiB) and CSF A beta 42 in AD. Methods: A group of 30 patients with probable AD, as defined by established clinical criteria and by an AD-typical pattern of tracer uptake in fluorine-18-labeled fluorodeoxyglucose ([F-18]FDG) PET, were included. In all patients, [C-11]PiB PET and CSF analysis were performed. The association between amyloid load and CSF A beta 42 levels was examined in three different ways: by linear regression analysis using an overall [C-11]PiB value for the entire cerebrum, by correlation analyses using [C-11]PiB measurements in anatomically defined regions of interest, and by voxel-based regression analyses. Results: All patients showed a positive [C-11]PiB scan demonstrating amyloid deposition. Linear regression analysis revealed a significant inverse correlation between the overall [C-11]PiB uptake and CSF A beta 42 levels. Voxel-based regression and regional correlation analyses did not attain statistical significance after correction for multiple comparisons. Numerically, correlation coefficients were higher in brain regions adjacent to CSF spaces. Conclusions: The study demonstrates a moderate linear negative association between cerebral amyloid plaque load and CSF A beta 42 levels in AD patients in vivo and suggests possible regional differences of the association.
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