Journal
BIOLOGICAL PSYCHIATRY
Volume 66, Issue 1, Pages 69-75Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2009.02.030
Keywords
Childhood abuse; cortisol; depression; HPA axis; mood disorders
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Funding
- NIMH NIH HHS [R01 MH068767, R01 MH068767-02, R01 MH068767-03, R01 MH068767-04, R01 MH068767-01A1] Funding Source: Medline
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Background: The dexamethasone/corticotropin releasing hormone (Dex/CRH) test has been proposed as a potential tool for identifying endophenotypes relevant to mood disorders. Several studies have shown abnormal cortisol reactivity in phenotypically healthy adults without psychiatric disorders as a function of exposure to adverse early environments. Methods: After a battery of self-report and interview assessments, 230 adults without major Axis I Disorders completed the Dex/CRH test. Childhood maltreatment was evaluated with the Childhood Trauma Questionnaire. Effect of childhood emotional abuse (EA) on cortisol responses to the Dex/CRH test was examined with repeated measures general linear models, including age, gender, and other types of maltreatment. Post hoc models examined the significant interaction between EA and age and tested the stability of the main findings with selected covariates. Results: A history of self-reported childhood EA independently and significantly diminished cortisol response. This effect was amplified with advancing subject age and was independent of the effects of other types of childhood maltreatment, lifetime diagnoses, and symptom scores. Conclusions: Dampened cortisol reactivity might be a consequence of childhood EA that is cumulative overtime. Prospective longitudinal investigation is needed to evaluate the potential of this proposed endophenotype.
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