Journal
BIOLOGICAL PSYCHIATRY
Volume 65, Issue 3, Pages 211-219Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2008.06.009
Keywords
Depression; 5-HTTLPR; Gene x Environment interaction; meta-analysis; stressful life events
Categories
Funding
- National Alliance for Research on Schizophrenia and Depression Young Investigator Award
- Medical Research Council fellowship
- Wellcome Trust
- MRC [G0501318] Funding Source: UKRI
- Medical Research Council [G0501318] Funding Source: researchfish
Ask authors/readers for more resources
Background: Although it is universally accepted that human disease and behavior depend upon both environmental and genetic variation, a view supported by family and twin studies, examples of environmental interactions with genes identified at the molecular level (G x E) are not so well established. Methods: We carried out a systematic review and meta-analysis of the serotonin transporte (5-HTTLPR) polymorphic region x stressful life event (SLE) literature and investigated to what extent the main effects reported in this literature are consistent with a number of G x E hypotheses. Our aim was to provide a framework in which to assess the robustness of the claim for the presence of an interaction. Results: The results from our systematic review and meta-analysis indicate that the main effect of 5-HTTLPR genotype and the interaction effect between 5 -HTTLPR and SLE on risk of depression are negligible. We found that only a minority of studies report a replication that is qualitatively comparable to that in the original report. Conclusions: Given reasonable assumptions regarding likely genetic and environmental effect sizes, our simulations indicate that published studies are underpowered. This, together with other aspects of the literature, leads us to suggest that the positive results for the 5-HTTLPR x SLE interactions in logistic regression models are compatible with chance findings.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available