Journal
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
Volume 4, Issue 4, Pages 423-430Publisher
ACADEMIC PRESS INC
DOI: 10.1006/niox.2000.0294
Keywords
nitric oxide; Drosophila; immunity; reactive oxygen species; reactive nitrogen species
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Funding
- NIGMS NIH HHS [GM59774] Funding Source: Medline
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The augmented production of nitric oxide (NO) was observed during the hemocyte-mediated melanotic encapsulation responses of Drosophila melanogaster and D. teissieri. When introduced into the hemocoel of D. melanogaster larvae, NO activated the gene encoding the antimicrobial peptide Diptericin. These observations, together with previous studies documenting the production of superoxide anion (O-2(.-)) and H2O2 in immune-challenged Drosophila, provide evidence that reactive intermediates of both oxygen (ROI) and nitrogen (RNI) constitute a part of the cytotoxic arsenal employed by Drosophila in defense against both microbial pathogens and eukaryotic parasites. These ROI and RNI appear to represent an evolutionarily conserved innate immune response that is mediated by regulatory proteins that are homologous to those of mammalian species. (C) 2000 Academic Press.
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