Journal
BIOLOGICAL PSYCHIATRY
Volume 66, Issue 3, Pages 245-252Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2009.02.032
Keywords
Depression; diffusion tensor imaging; geriatrics; MRI; segmentation
Categories
Funding
- NARSAD [MH60697, K24 MH079510]
- NIH [K23 HD053212]
Ask authors/readers for more resources
Background: Many recent studies have identified white matter abnormalities in late life depression (LLD). These abnormalities include an increased volume of discrete white matter hyperintensities on T2-weighted imaging (WMH) and changes in the diffusion tensor properties of water. However, no study of LLD to date has examined the integrity of white matter outside of WMH (i.e., in normal-appearing white matter). Methods: We performed T1- and T2-weighted imaging as well as diffusion tensor imaging (DTI) in depressed elderly subjects (n = 73) and nondepressed control subjects (n = 23) matched forage and cerebrovascular risk factors. The structural images were segmented into white matter, gray matter, cerebrospinal fluid, and WMH. The DTI parameters were calculated in white matter regions of interest after excluding the WMH. Results: Compared with control subjects, in the LLD group there were widespread abnormalities in DTI parameters, particularly in prefrontal regions. From a comprehensive neuropsychological battery, the strongest correlations were observed between cognitive processing speed and DTI abnormalities. Conclusions: These results suggest that further investigation is warranted to determine potential reversibility and/or prognosis in LLD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available