Journal
BIOLOGICAL PSYCHIATRY
Volume 66, Issue 11, Pages 1005-1012Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2009.07.027
Keywords
Association study; copy number variation; neurodevelopment; schizophrenia; synapse
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Funding
- The Wellcome Trust
- The Wellcome Trust Genes to Cognition Programme
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Schizophrenia is a major psychiatric disease with strong evidence of genetic risk factors. Recent studies based on genome-wide study of copy number variations (CNVs) have detected novel recurrent submicroscopic copy number changes, including recurrent deletions at 1q21.11, 15q11.3, 15q13.3, and the recurrent CNV at the 2p16.3 neurexin 1 locus. These schizophrenia susceptibility CNV loci demonstrate that schizophrenia is, at least in part, genetic in origin and provide the basis for further investigation of mutations associated with the disease. The studies combined have also established the role of rare and-in sporadic cases-de novo variants in schizophrenia. Furthermore, neuronal-related genes and genetic pathways are starting to emerge from the CNV loci associated with schizophrenia. Here, we review the major findings in the recent literature, which begin to unravel the genetic and biological architecture of this complex human neuropsychiatric disorder.
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