Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 97, Issue 16, Pages 8789-8793Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.97.16.8789
Keywords
bacterial signaling; biofilms; pathogenesis; Pseudomonas aeruginosa; virulence mechanisms
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Funding
- NIGMS NIH HHS [R01 GM059026, GM59026] Funding Source: Medline
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Recent advances in studies of bacterial gene expression have brought the realization that cell-to-cell communication and community behavior are critical for successful interactions with higher organisms. Species-specific cell-to-cell communication is involved in successful pathogenic or symbiotic interactions of a variety of bacteria with plant and animal hosts. One type of cell-cell signaling is acyl-homoserine lactone quorum sensing in Gram-negative bacteria. This type of quorum sensing represents a dedicated communication system that enables a given species to sense when it has reached a critical population density in a host, and to respond by activating expression of genes necessary for continued success in the host. Acyl-homoserine lactone signaling in the opportunistic: animal and plant pathogen Pseudomonas aeroginosa is a model for the relationships among quorum sensing, pathogenesis, and community behavior, In the P. aeroginosa model, quorum sensing is required for normal biofilm maturation and for virulence. There are multiple quorum-sensing circuits that control the expression of dozens of specific genes that represent potential virulence loci.
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