Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 35, Issue 2, Pages 109-120Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S1040-8428(00)00053-6
Keywords
novel; trans-platinum; antitumor complexes
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The discovery in the 1990s of several trans-Pt complexes with in vitro and in vivo activity against tumor cells sensitive and/or resistant to cisplatin has forced the re-evaluation of the structure-activity relationships for platinum antiturnor drugs. Because the determinant factors of cytotoxic activity of trans-platinum complexes do not follow the same patterns as those found for cisplatin and its analogues, the differences in cellular and biochemical pharmacology between trans-platinum antitumor complexes and cisplatin might be systematically exploited to design novel trans-platinum complexes with a clinical profile complementary to that of cisplatin and related analogues. Therefore, there may exist a novel molecular rationale for new platinum antitumor drugs development in the twenty-first century. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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