Journal
LEUKEMIA RESEARCH
Volume 24, Issue 8, Pages 671-680Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0145-2126(00)00037-0
Keywords
regrowth resistance; suppression of telomerase activity
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Funding
- NCI NIH HHS [1PO-1CA75606] Funding Source: Medline
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Twenty patients with poor prognosis AML and four patients in the blastic phase of a myeloproliferative disorder were treated with two 'pulses' of therapy each consisting of two doses of high dose araC (separated by 12 h) followed by a single dose of mitoxantrone. The pulses were separated by 96 h. Amifostine was then administered tiw. The median age of the population was 68 years with 88% of patients having had either a prior MDS, MPD or toxic exposure. The acute leukemia of 58% of patients either entered a CR or reverted to preleukemic state. For patients under 70 years of age, treatment produced 62% CRs with a leukemia free decision marrow in 77%. For patients over 70 years the CR rate was 27% with 36% of patients having a leukemia free decision marrow. (C) 2000 Elsevier Science Ltd. All rights reserved.
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