Journal
FEMS MICROBIOLOGY LETTERS
Volume 189, Issue 1, Pages 93-95Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-1097(00)00259-7
Keywords
isoprenoid; hopanoid; differentiation; Streptomyces coelicolor
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Streptomyces coelicolor A3(2) contains a cluster of putative isoprenoid and hopanoid biosynthetic genes. The strain does not produce the pentacyclic hopanoids in liquid culture but produces them on solid medium when sporulating. Mutants defective in the formation of aerial mycelium and spores (bld), with the exception of bldB, do not synthesize hopanoids, whereas mutants, which form aerial mycelium but no spores (whi), do. The membrane condensing hopanoids possibly may alleviate stress in aerial mycelium by diminishing water permeability across the membrane. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
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