Journal
BIOLOGICAL PSYCHIATRY
Volume 64, Issue 6, Pages 541-544Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2008.04.032
Keywords
cognitive deficit; gray matter; magnetic resonance imaging (MRI); remitted geriatric depression; voxel-based morphometry
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Funding
- National Natural Science Foundation of China [30770779 ZZ]
- National Basic Research Program, of China (973 Program) [2007CB512308 ZZ]
- National Hi-Tech Research and Development Program of China (863 Program) [2007AA0200Z435 ZZ)]
- Key Program of Medical Development of Nanjing [ZKX07018 YY]
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Background: We aimed to investigate structural abnormalities in first-episode remitted geriatric depression (RGD) with optimized voxel-based morphometry (VBM) in closely matched patients and healthy control subjects and examine the relationship of performances on neuropsychological tests with regional gray matter volumes. Methods: Nineteen subjects with first-episode RGD and 16 well-matched healthy control subjects were recruited for this study, and neuropsychological tests and magnetic resonance imaging were conducted on the subjects. The differences in regional gray matter volume were determined between these two groups by optimized VBM. Results: The volumes of right superior frontal cortex, left postcentral cortex, and right middle temporal gyrus were significantly smaller in patients with RGD relative to healthy control subjects. However, patients with RGD had larger left cingulate gyrus volume compared with healthy control subjects. There was a significant negative correlation between left cingulate gyrus volume and Rey Auditory Verbal Learning Test delayed recall raw score in patients with RGD. Conclusion: These results reveal that RGD is associated with gray matter changes of certain brain regions hypothesized to influence cognition and might thus be involved in the psychopathology and pathophysiology of cognitive impairment in RGD.
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