Journal
BIOLOGICAL PSYCHIATRY
Volume 63, Issue 3, Pages 256-262Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2007.06.003
Keywords
drug cues; orbitofrontal cortex; reinstatement; relapse; reversal learning; stress
Categories
Funding
- Intramural NIH HHS Funding Source: Medline
- NIDA NIH HHS [R01 DA015718, R01 DA015718-03, R01 DA015718-02S1, R01 DA015718-03S1, R01-DA015718, R01 DA015718-01A1, R01 DA015718-05, R01 DA015718-02, R01 DA015718-04] Funding Source: Medline
Ask authors/readers for more resources
Studies using brain imaging methods have shown that neuronal activity in the orbitofrontal cortex, a brain area thought to promote the ability to control behavior according to likely outcomes or consequences, is altered in drug addicts. These human imaging findings have led to the hypothesis that core features of addiction like compulsive drug use and drug relapse are mediated in part by drug-induced changes in orbitofrontal function. Here, we discuss results from laboratory studies using rats and monkeys on the effect of drug exposure on orbitofrontal-mediated learning tasks and on neuronal structure and activity in orbitofrontal cortex. We also discuss results from studies on the role of the orbitofrontal cortex in drug self-ad ministration and relapse. Our main conclusion is that although there is clear evidence that drug exposure impairs orbitofrontal-dependent learning tasks and alters neuronal activity in orbitofrontal cortex, the precise role these changes play in compulsive drug use and relapse has not yet been established.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available