Journal
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume 9, Issue 8, Pages 1731-1742Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543784.9.8.1731
Keywords
antimicrobial peptides; oral mucositis; structure-function studies; topical antimicrobials
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Protegrins and their derivatives are a new class of peptide antibiotics based on mammalian antimicrobial peptides. Their pharmacological properties include an unusually broad spectrum of antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi and some enveloped viruses. Preclinical and clinical studies of the lead compound, IB-367, developed for topical applications, show promise for the prevention of chemotherapy- and radiation-induced oral mucositis.
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