Journal
CYTOKINE
Volume 12, Issue 8, Pages 1284-1287Publisher
W B SAUNDERS CO
DOI: 10.1006/cyto.1999.0731
Keywords
Caco-2; IL-8; lectins
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Cultured Caco-2 cells were stimulated with Lens culinaris, Phaseolus vulgaris and Vicia faba lectins, The production of IL-1, IL-6, IL-8 and MCP-1 was measured by ELISA and RT-PCR, IL-8 production appeared to be specifically triggered upon stimulation with all three lectins used, since none of the other cytokines tested were produced. The IL-8 secreted may induce the extravasation of activated neutrophils and generate tissue damage. A similar mechanism may be implicated in the lesions observed after infection by some enteric pathogens, with lectin-like domains on their membrane, Finally, this model may be suitable one to study the regulation of IL-8 production. (C) 2000 Academic Press.
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