Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 57, Issue 8-9, Pages 1149-1160Publisher
BIRKHAUSER VERLAG AG
DOI: 10.1007/PL00000755
Keywords
transcription; preinitiation complex; promoter; RNA polymerase II
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Transcriptional regulators contain domains that either activate or repress transcription. Indeed, many cellular transcriptional regulators contain both activation and repression domains. Transcriptional regulators act at several stages in the transcription process, including assembly of the transcription complex, initiation and elongation. In order to influence these processes, the regulatory domains must interact with components of the transcription apparatus. This review will focus on our current understanding of the nature of transcriptional regulatory domains and their targets in the transcription machinery.
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