Journal
JOURNAL OF VIROLOGY
Volume 74, Issue 16, Pages 7642-7645Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.74.16.7642-7645.2000
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Funding
- NIAID NIH HHS [R01 AI039416] Funding Source: Medline
- NIDDK NIH HHS [R01 DK043727, DK47754, R01 DK050246, DK43727, P30 DK047754, DK50686] Funding Source: Medline
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Intestinal epithelial cells secrete a protective luminal mucus barrier inhibiting viral gene transfer. Quiescent, polarized monolayers of primary epithelial cells from dog gallbladder and human colon are efficiently transduced through the apical mucus side by lentivirus vectors, suggesting their application to intestinal gene therapy.
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