Journal
JOURNAL OF APPLIED PHYSIOLOGY
Volume 89, Issue 2, Pages 840-847Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jappl.2000.89.2.840
Keywords
gravity; osteoporosis; weightlessness; space travel; microgravity; mineral metabolism
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This review of the peer-reviewed literature focuses on the effects of spaceflight on bone. Studies performed in humans and laboratory animals have revealed abnormalities in bone and mineral metabolism that suggest that long-duration spaceflight will have detrimental effects on the skeleton. However, because of large gaps in our knowledge, it is not;presently possible to estimate the magnitude of the health risk, individual variations in risk, effective countermeasures, or mechanism(s) of action. Specific recommendations are made for future research to ascertain risk and develop appropriate countermeasures.
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