Journal
MOLECULAR NEUROBIOLOGY
Volume 22, Issue 1-3, Pages 129-141Publisher
HUMANA PRESS INC
DOI: 10.1385/MN:22:1-3:129
Keywords
dendrites; excitability; pyramidal neurons; backpropagation; intracellular signaling; G protein; protein kinase; calcium
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The integrative function of neurons depends on the somato-dendritic distribution and properties of voltage-gated ion channels. Sodium, potassium, calcium, and hyperpolarization-activated cyclic nucleotide-gated K+ (HCN) channels expressed in the dendrites can be modulated by a number of neurotransmitters and second-messenger systems. For example, activation of protein kinases leads to an increase in dendritic excitability by removing a slow inactivation of Na+ channels and decreasing the activity of transient K+ channels in the apical dendrites of hippocampal pyramidal neurons. Consequently, action potentials propagating along the dendrites can be modified significantly by a variety of neuromodulatory synaptic inputs.
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