Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 108, Issue 1-2, Pages 82-91Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(00)00253-8
Keywords
alpha(1)-adrenergic receptor; human peripheral blood mononuclear cells extracellular signal regulated kinase-2 catecholamine
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alpha(1)-Adrenergic receptors (ARs) are not expressed by peripheral blood mononuclear cells (PBMCs) of healthy human individuals. However, in the present study we show that alpha(1)-ARs can be induced in lymphocytes after culturing with either the mitogen PHA or the glucocorticoid dexamethasone. Moreover, incubation of these activated PBMCs with noradrenaline (NA) results in enhanced phosphorylation of ERK-2 a kinase involved in the activation of many immune functions. Similar induction of alpha(1)-AR mRNA with concomitant NA-induced activation of ERK-2 occurs in monocytes after culture with LPS. Our results demonstrate that functional alpha(1)-ARs can be induced on PBMCs and that these alpha(1)-ARs mediate NA-induced activation of ERK-2. (C) 2000 Elsevier Science B.V. All rights reserved.
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