Journal
MOLECULAR GENETICS AND METABOLISM
Volume 70, Issue 4, Pages 241-251Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/mgme.2000.3033
Keywords
stroke; coronary artery disease; hypertension; renal disease; eNOS polymorphism; cigarette smoking
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Genes contribute significantly to interpopulation differences in vascular disease, Endothelial nitric oxide synthase (eNOS)-a key regulator of vascular nitric oxide production-has been investigated extensively to determine the relevance of DNA variants in the eNOS gene and vascular diseases. Variants in the promoter region, introns, and exons have been explored in a large number of populations but findings have been inconsistent. This paper reviews the current status of functional significance for reported sequence variations in the eNOS gene and the relevance of these variants to different forms of vascular diseases. (C) 2000 Academic Press.
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