Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 4, Issue 4, Pages 461-467Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1367-5931(00)00103-4
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Type 2 diabetes is a chronic metabolic derangement that results from defects in both insulin action and secretion. New thiazolidinedione insulin sensitizers have been recently launched. New approaches with mechanisms different from current therapies are being explored, including novel ligands of peroxisome proliferator-activated receptor, glucagon receptor antagonists, dipeptidyl peptidase IV inhibitors, and insulin receptor activators.
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