Changes in immune function with age

Aging is accompanied by a decline in the effectiveness of a number of immune functions. This has been termed immunosenescence. Changes identified to date suggest that the major defects reside in the T cell immune compartment. Recent research also suggests that alteration in B cell and other immune cells may play an important role in defining the immune competency in the elderly. These changes have been linked to reduced responses to immunization, and increased rate of infection, cancer, and mortality in aging. In the era of the aging baby boomers, it is important for all clinicians to understand these changes and their implications.