Journal
CHEMICAL SENSES
Volume 25, Issue 4, Pages 473-481Publisher
OXFORD UNIV PRESS
DOI: 10.1093/chemse/25.4.473
Keywords
-
Funding
- NIDCD NIH HHS [DC003773, DC00347] Funding Source: Medline
- NINDS NIH HHS [NS37748] Funding Source: Medline
Ask authors/readers for more resources
An important recent advance in the understanding of odor adaptation has come from the discovery that complex mechanisms of odor adaptation already take place at the earliest stage of the olfactory system, in the olfactory cilia. At least two rapid forms and one persistent form of odor adaptation coexist in vertebrate olfactory receptor neurons. These three different adaptation phenomena can be dissected on the basis of their different onset and recovery time courses and their pharmacological properties, indicating that they are controlled, at least in part, by separate molecular mechanisms. Evidence is provided for the involvement of distinct molecular steps in these forms of odor adaptation, including Ca2+ entry through cyclic nucleotide-gated (CNG) channels, Ca2+-dependent CNG channel modulation, Ca2+/calmodulin kinase Ii-dependent attenuation of adenylyl cyclase, and the activity of the carbon monoxide/cyclic GMP second messenger system. Identification of these molecular steps may help to elucidate how the olfactory system extracts temporal and intensity information and to which extent odor perception is influenced by the different mechanisms underlying adaptation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available