Journal
TRENDS IN MICROBIOLOGY
Volume 8, Issue 8, Pages 354-360Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0966-842X(00)01792-3
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Funding
- NIGMS NIH HHS [GM48746, R01 GM048746] Funding Source: Medline
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Several bacterial pathogens utilize conjugation machines to export effector molecules during infection. Such systems are members of the type IV or 'adapted conjugation' secretion family. The prototypical type TV system is the Agrobacterium tumefaciens T-DNA transfer machine, which delivers oncogenic nucleoprotein particles to plant cells. Other pathogens, including Bordetella pertussis, Legionella pneumophila, Brucella spp. and Helicobacter pylori, use type IV machines to export effector proteins to the extracellular milieu or the mammalian cell cytosol.
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