Journal
NEUROREPORT
Volume 11, Issue 11, Pages 2385-2390Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200008030-00010
Keywords
c-Fos; harmaline; inferior olive; oxotremorine; rat; striatum; tremor
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The regional distribution of c-Fos expression in the brain after the administration of two tremorgenic agents was studied. In both the harmaline- and oxotremorin-treated rats, c-fos-positive neurons were extensively distributed in the basal ganglia nuclei and the cerebellum. Additionally, in the harmaline-treated rats, numerous c-fos-positive neurons were also distributed throughout the inferior olivary nucleus. In the oxotremorine-treated rats, while the inferior olive was not involved, c-Fos was strongly expressed in the neurons of the reticular thalamic nucleus, possibly due to the muscarinic effects of oxotremorine. The present study revealed that the inferior olive is selectively activated in the harmaline-administered animals and that the basal ganglia are involved in both harmaline- and oxotremorine-induced tremors. NeuroReport 11:2385-2390 (C) 2000 Lippincott Williams & Wilkins.
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