Journal
NEUROREPORT
Volume 11, Issue 11, Pages 2507-2509Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200008030-00032
Keywords
ALS; DNA; mitochondria; mutation; neurodegeneration
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Funding
- NIA NIH HHS [AG-05142] Funding Source: Medline
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This study was performed to explore the potential role of mitochondrial DNA mutations in the neurodegenerative process in amyotrophic lateral sclerosis (ALS). Using a semiquantitative assay, a common mitochondrial DNA deletion mutation (mt DNA(4977)) was assayed in brain tissue obtained from six sporadic ALS patients and compared to four controls. In each brain, levels of this mutation were measured in a brain region affected by neurodegeneration, the motor cortex (Brodmann area 4), and compared to the temporal cortex (Brodmann area 17). In the ALS but not control brains, levels of mt DNA(4977) were an average of more than 30-fold (range 15-250) higher in Brodmann area 4. These results support and extend those of previous studies implying that mitochondria may participate in the neurodegenerative process in ALS. NeuroReport 11:2507-2509 (C) 2000 Lippincott Williams & Wilkins.
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