Journal
TETRAHEDRON LETTERS
Volume 41, Issue 32, Pages 6111-6114Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(00)01023-6
Keywords
Illicium merrillianum; sesquiterpene lactone; merrilactone A; structure elucidation; neurotrophic activity
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Merrilactone A, isolated from the pericarps of Illicium merrillianum, shows an intriguing neurotrophic activity in the cultures of fetal rat cortical neurons. Its structure has been elucidated to be a unique sesquiterpene bearing two gamma-lactones and an oxetane ring by extensive analyses of spectral data and then confirmed by X-ray crystallographic analysis. Further, the absolute configuration has been established by the modified Mosher's method. (C) 2000 Elsevier Science Ltd. All rights reserved.
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