Journal
CARBOHYDRATE RESEARCH
Volume 327, Issue 4, Pages 353-365Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0008-6215(00)00073-2
Keywords
glycosides; neurologically active compounds; neurotransmitter; glucose carrier
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A new approach to deliver dopamine into the central nervous system, based on the use of D-glucose as transportable agent, has been studied. Glycosyl dopamine derivatives bearing the sugar moiety linked to either the amino group or the catechol ring of dopamine through amide, eater or glycosidic bonds were synthesised as potential antiparkinsonian agents. Studies on the binding to dopamine D-2 receptor, in vitro stability, and locomotive effect in mice of the synthetic glycoconjugates are reported. (C) 2000 Elsevier Science Ltd. All rights reserved.
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